New Synthesis and Antiparasitic Activity of Model 5-Aryl-1-methyl-4-nitroimidazoles
نویسندگان
چکیده
منابع مشابه
New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles.
A number of 5-aryl-1-methyl-4-nitroimidazoles 5a-f have been synthesized in good yields by the Suzuki coupling reaction between 5-chloro-1-methyl-4-nitroimidazole (3) and arylboronic acids 4a-f, aided by dichlorobis-(triphenylphosphine)palladium(II), K(2)CO(3, )and tetrabutylammonium bromide in water at 70-80 degrees C. Compounds 5a-f were characterized by elemental analysis, NMR and MS spectra...
متن کاملPYRAZOLINES AND ISOXAZOLINES (I). SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF P-(1-ACYL-3-METHYL-5-ARYL-4 PYRAZOLINOYL / P-(3-METHYL-5-ARYL-4ISOXAZOLINOYL) ARSANILIC ACID
4-(acetoacetamido) arsanilic acid (II), which was then condensed with aryl aldehydes. The resulting product on reaction with hydrazine hydrate and hydroxyl amine hydrochloride yielded Pyrazolines (IV) and Isoxazolines (V), respectively. The antimicrobial activity of compounds against a number of microorganisms was evaluated. Some of these compounds showed significant antimicrobial activity
متن کاملSynthesis, Characterization and Study of Some N-Substituted Aryl-2- ({4-[(Substituted Aryl Carbamoyl) Methyl]-5-(Pyridin-4-yl)-4H-1, 2, 4-Triazol-3-yl} Sulfanyl) Acetamide
Pathogenic infections and inflammation are very common ailments humans suffer. Upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. In line with these developments the synthesis of N-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4H-1...
متن کاملSynthesis and Biological activity of new 5-Methyl-3-Oxo-N2 [5’- Carbonyl-(4’-Aryl-6’methyl)-1’,2’,3’,4’–Tetrahydropyrimidine-2’- One]Pyrazolidines
INTRODUCTION In recent years, synthesis of combination towards various heterocyclic rings has been interest for the source of lead molecules possesses wide range of pharmacological activities. Most of the compounds having pyrimidine and pyrazolidinone nucleus exhibits pharmacological action. [1-3].A broad spectrum of biological activities like antiinflammatory [4], antibacterial [5], antifungal...
متن کاملpyrazolines and isoxazolines (i). synthesis and antimicrobial activities of p-(1-acyl-3-methyl-5-aryl-4 pyrazolinoyl / p-(3-methyl-5-aryl-4isoxazolinoyl) arsanilic acid
4-(acetoacetamido) arsanilic acid (ii), which was then condensed with aryl aldehydes. the resulting product on reaction with hydrazine hydrate and hydroxyl amine hydrochloride yielded pyrazolines (iv) and isoxazolines (v), respectively. the antimicrobial activity of compounds against a number of microorganisms was evaluated. some of these compounds showed significant antimicrobial activity
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 2009
ISSN: 1420-3049
DOI: 10.3390/molecules14082758